Novel Drug Delivery System Multiple Choice Questions
1. Liposomes are spherical structures, usually between in diameter……………..
A. 80nm-100nm
B. 60nm-100nm
C. 55nm-1000nm
D. 15nm-1000nm
Answer: D
2. Liposomes consists of a bilayer of…………………
A. Hydrophilic molecules
B. Hydrophobic molecules
C. Both a and b
D. None
Answer: C
3. Liposomes have half-life …………….
A. Longer
B. Shorter
C. Intermediate
D. Both a and b
Answer: B
4. Liposome phospholipids undergoes ………………
A. Oxidation
B. Hydrolysis
C. Acetylation
D. Both a and b
Ans. : b
5. Intermediate sized unilamellar vesicles are prepared by
A. Sonication
B. High pressure extrusion technique
C. Detergent dialysis
D. Both b and c
Answer: D
6. The diameter of Small unilamellar vesicles is
A. 20-100nm
B. 20-1000nm
C. 10-100nm
D. 100nm-400nm
Ans. : a
7. Tranfersome belongs to the classification according to
A. Composition
B. Application
C. Function
D. None of the above
Answer: C
8. Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”.
A. Lower
B. Higher
C. Single
D. None of the above
Answer: A
9. Passive Loading Technique includes…………..
A. Lyophilization
B. Proliposomes
C. Solvent dispersion
D. Both a and b
Ans. : c
10. Loading of the entrapped agents before/during the manufacture procedure is known as…………
A. Active loading
B. Passive loading
C. Both a and b
D. None of the above
Answer: B
11. Drawback of Lipid hydration method is
A. Low internal volume
B. High encapsulation efficiency
C. Size distribution is homogenous
D. None of the above
Answer: A
12. Tip of sonicator is directly engrossed into liposome dispersion in……………
A. Bath sonication
B. Probe sonication
C. None of the above
Answer: B
13. The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs.
A. Smaller
B. Equal
C. Larger
Answer: C
14. To produce a microemulsion of small vesicles at least _______ circulations are required
A. at least 20 circulation but not greater than 200
B. 10 circulations
C. at least 200 circulation but not greater than 2000
D. at least 2 circulations but not greater than 10
Answer: A
15. Dried reconstituted vesicles method is performed in…………..
A. Solvent dispersion
B. Mechanical dispersion
C. Both a and b
Answer: B
16. Solvent vaporization is also known as………………….
A. Ether injection
B. Ethanol injection
C. Double emulsification
D. Reverse-phase evaporation
Answer: A
17. Temperature used for Ether Injection method is______ or under reduced pressure.
A. 15-25 ̊C
B. 55-65 ̊C
C. 55-85 ̊C
D. None of the above
Ans. : b
18. Ketoconazole liposomes are given by…………….
A. Lungs
B. Oral
C. Transdermal
D. Intravenous
Ans. : c
19. Amphotericin B liposomes are given……………..
A. Lungs
B. Oral
C. Transdermal
D. Intravenous
Answer: B
20. In niosomes phospholipids are ………………
A. Present
B. Absent
C. Both a or b
D. None
Ans. : a
21. Pharmacosome belongs to the classification according to
A. Composition
B. Function
C. Application
D. None of the above
Ans. : b
22. Which of the following can be incorporated into a liposome?
A. Only drugs and viruses
B. Only Peptides and viruses due to similar characteristics
C. Only viruses
D. Drugs, peptides, viruses, bacteria
Ans. : d
23. How are MLV liposomes made?
A. 2-10 bilayers of lipid
B. Series of concentric bilayers of lipid
C. The single bilayer of lipid
D. 100 bilayer of lipid
Ans. : b
24. How are OLV liposomes made?
A. 2-10 bilayers of lipid
B. Series of concentric bilayers of lipid
C. A single bilayer of lipid
D. 100 bilayer of lipid
Answer: A
25. Which of the following is a characteristic of the parental controlled drug release system by liposomes?
A. Free flowing powders
B. Aqueous solutions
C. Lipid bilayer enclosing the drug
D. Administration of emulsions
Ans. : c
26. Which of the following drugs can not be given as transdermal administration?
A. Drugs with very short half life
B. Drugs with narrow therapeutic index
C. Easy removal and termination
D. Drug against peptic ulcer
Answer: D
27. What are the characteristics of the monolithic devices?
A. The drug has a large therapeutic index
B. Aqueous solution
C. Control drug release by partitioning the drug from oil
D. Administration of emulsion
Answer: A
28. Which of the following characteristics is suitable for transdermal drug?
A. Large drug dose
B. Large molecular size
C. Drugs with narrow therapeutic index
D. Drug which are metabolized in the skin
Answer: C
29. The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.
A. Square of time
B. The square root of time
C. Twice the time
D. Half the time
Answer: B
30. What are the characteristics of the reservoir or membrane devices?
A. The drug has a large therapeutic index
B. Drug permeation rate is high
C. Control drug release by partitioning the drug from oil
D. Administration of emulsion
Answer: B
31. What are the characteristics of the mixed monolithic reservoir devices?
A. The drug has a large therapeutic index
B. Drug permeation rate is high
C. The drug polymer matrix is layered by rate controlling membrane
D. Administration of emulsion
Answer: C
32. Which of the following is false in regarding reservoir devices?
A. These devices are used when the drug permeation rate is rapid
B. The release of the drug is controlled
C. Suitable for low therapeutic index
D. The drug is contained in a powder from floating on liquid
Answer: D
33. Which of the following is true for monolithic devices?
A. These devices are used when the drug permeation rate is rapid
B. The release of the drug is controlled
C. Suitable for drugs with large therapeutic index
D. The drug is contained in a powder form floating on liquid
Answer: C
34. The absorption of the ophthalmic drug does not depend on which of the following?
A. Physicochemical properties of permeating molecule
B. Drainage of tears
C. Output of tears
D. Size of the eyeball
Answer: D
35. Which of the following is false for monolithic devices?
A. The drug used for these devices has large therapeutic index
B. There are three categories of matrix devices
C. 1st type has the drug dissolved in the polymer matrix
D. 2nd type has drug delivery
Answer: B
36. Problems with opioid TDDS include.
A. Poor patient compliance
B. Allergy
C. Constipation.
D. Respiratory depression.
Answer: B
37. Regarding the skin:
A. The epidermis is the thickest layer.
B. The stratum corneum is the greatest barrier to transdermal transport.
C. The dermis has a rich capillary blood supply.
D. Skin hydration is a cause of inter-individual variation in drug absorption.
Answer: D
38. How much thickness of the dermis layer?
A. 2 to 7 nm
B. 3 to 5 nm
C. 3 to 6 nm
D. 5 to 8 nm
Answer: B
39. TDDS is usually only suitable for drugs of what level of potency?
A. Typically only for drugs of high potency.
B. Low potency
C. High to low potency
D. Low to high potency
Answer: A
40. In the use of TDDS for drug application ? size has to be considered reasonable?
A. Strip size
B. Patch size
C. Film size
D. Diskette size
Answer: B
41. What is the largest organ of the body?
A. Liver
B. Lungs
C. Skin
D. Brain
Answer: C
42. Which of the following is false for Merits of the TDDS.
A. Avoidance of the First pass effect
B. A stable and controlled blood level
C. Termination at any time is conceivable
D. Skin irritation and allergic response
Answer: D
43. How many layer are seen in monolithic TDDS design?
A. 4
B. 3
C. 5
D. 2
Ans.: 3
44. How many layer are seen in membrane-controlled system?
A. 3
B. 5
C. 4
D. 6
Answer: C
45. A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.
A. Iontophoresis
B. Sonophoresis
C. Electrophoresis
D. Ion exchange
Answer: A
46. A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability.
A. Iontophoresis
B. Sonophoresis
C. Electrophoresis
D. Ion exchange
Answer: B
47. Which component are not included in combination of the SEDDS formulation?
A. Oil
B. Lipid
C. Drug
D. Wax
Answer: D
48. SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________.
A. GIT
B. RT
C. UT
D. Liver
Answer: A
49. SEDDSs produce emulsion with droplet size between ____________.
A. 200 to 400nm
B. 100 to 300nm
C. 10 to 100nm
D. 1000nm
Answer: B
50. Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________.
A. 50 nm
B. 70 nm
C. 100 nm
D. 200 nm
Answer: A
51. Which sentence is false in the merits of SEDDS?
A. Quick onset of action
B. Increase the Drug Dose.
C. Ease of manufacture & Scale up.
D. Improvement in oral bioavailability.
Answer: B
52. Which one more convenient route of administration for SEDDS.
A. Oral
B. I.V
C. I.M
D. Skin
Answer: A
53. Which of the following false for in example of oil in SEDDS?
A. Corn oil
B. Olive oil
C. Sesame oil
D. Rice oil
Answer: D
54. Which of the following is false for in examples of Surfactant in SEDDS?
A. Polysorbate 20
B. Polysorbate 80
C. Span 20
D. Sorbitan monooleate
Answer: C
55. Which of the following is false for example of co-solvent?
A. Chloroform
B. Ethanol
C. Glycerin
D. Propylene glycol
Answer: A
56. Which are not Preferable route of administration for SEDDS?
A. Oral
B. Parenteral
C. Ophthalmic
D. Intra muscular
Answer: D
57. Mucoadhesive drug delivery system is a part of ___________delivery system?
A. Control
B. Sustained
C. Prolong
D. Target
Answer: A
58. Drug loading capacity of MDDS.
A. Low
B. High
C. Very low
D. Medium
Answer: B
59. Which theory use for the attractive electrostatic forces between glycoprotein Mucin network & the bio adhesive/ mucoadhesive material?
A. Electronic theory
B. Wetting theory
C. Adsorption theory
D. Diffusion theory
Answer: A
60. Which theory use for Physical entanglement of Mucin strands and flexible polymer chains.
A. Wetting theory
B. Adsorption theory
C. Diffusion theory
D. Fracture theory
Answer: C
61. Which route is not use for MDDS?
A. Nasal
B. Rectal
C. Oral
D. Buccal
Answer: C
62. Which polymers is not included in the semisynthetic class?
A. Chitosan
B. Gelatin
C. Pectin
D. Carbopol
Answer: D
63. Which polymers is not soluble in water?
A. PVP
B. CMC
C. PEG
D. HPMC
Answer: C
64. Which polymers are not having charge?
A. Starch
B. Amino dextran
C. Pectin
D. Sodium CMC
Answer: A
65. Which sentence is false in merits of MDDS?
A. Targeting & localization of the dosage form at a specific site
B. Painless administration
C. Low enzymatic activity & avoid of first pass metabolism
D. Some patient suffers unpleasant feeling
Answer: D
66. Which are the following not including in semisolid dosage form in MDDS?
A. Gel & ointment
B. Tablet
C. Films
D. Patches
Answer: B
67. What is the characteristics of mucoadhesive systems?
A. Release the drug along the entire length of GIT
B. Prolonged their residence in the GIT and release
C. Usage of bio adhesive polymer
D. Use of high or low density pellets
Answer: C
68. Mucoadhesive are including in which drug delivery system?
A. Target drug delivery system
B. Control drug delivery system
C. Prolong drug delivery system
D. Diffusion drug delivery system
Answer: B
69. Loading capacity of Mucoadhesive drug delivery system?
A. High
B. Poor
C. Medium
D. Very Poor
Answer: B
70. Howmany water percentage are present in Mucoadhesive drug delivery system?
A. 90 %
B. 80%
C. 95 %
D. 101%
Answer: C
71. Howmany nontechnology based product approved for clinical use?
A. 20
B. 24
C. 30
D. 10
Answer: B
72. What are the size of nanoparticles?
A. 10 – 100 nm
B. 1 – 100 nm
C. 10 – 1000 nm
D. None
Answer: B
73. Which of the following is a characteristic of nanoparticles?
A. Free flowing powders
B. Aqueous solutions
C. Control drug release by partitioning the drug from the oil
D. Size range 1 -100 nm
Ans. : d
74. Nanoparticles are dived in ………….. class ?
A. 3
B. 2
C. 4
D. 0
Answer: B
75. Which are protein is includes in natural protein ?
A. PECL
B. PLA
C. Gelatin
D. PMMA
Ans. c
76. Who first used the term Nanotechnology?
A. Richard Feymann
B. Norio Taniguichi
C. Eric Drexler
D. Sumio Lijima
Ans. : b
77. How many oxygen atoms lined up in a row would fit in a one nanometer space?
A. None
B. One
C. Seven
D. Seventy
Ans. c
78. Which of these statements is NOT true?
A. Gold at the nanoscale is red
B. Copper at the nanoscale is transparent
C. Silicon at the nanoscale is an insulator
D. Aluminium at the nanoscale is highly combustible
Answer: C
79. Which of the following is an example of top-down approach for the preparation of nanomaterials?
A. Gas phase agglomeration
B. Molecular self-assembly
C. Mechanical grinding
D. Molecular beam epitaxy
Answer: C
80. Which of the following is an example of bottom-up approach for the preparation of nanomaterials?
A. Etching
B. Dip pen nano-lithography
C. Lithography
D. Erosion
Answer: B
81. What is the general name for the class of structures made of rolled up carbon lattices?
A. Nanorods
B. Nanotubes
C. Nanosheets
D. Fullerods
Ans. : b
82. What ratio decides the efficiency of nano-substances?
A. Weight/Volume
B. Surface area/Volume
C. Volume/Weight
D. Pressure/Volume
Ans. : b
83. “There is plenty of room at the bottom”. This was stated by
A. Eric Drexler
B. Harold Croto
C. Richard Feymann
D. Richard Smalley
Answer: C
84. ____________ is the field in which the nanoparticles are used with silica coated iron oxide
A. Magnetic applications
B. Electronics
C. Medical diagnosis
D. Structural and mechanical materials
Ans. : c
85. Coating the nano crystals with the ceramics is carried that leads to__________ .
A. Corrosion
B. Corrosion resistant
C. wear and tear
D. Soft
Answer: B
86. Which of the ceramic components are easier through nano structuring?
A. Lubrication
B. Coating
C. Fabrication
D. Wear
Ans. : c
87. How is nanotechnology used in the medical community?
A. Testing and diagnosis
B. Tissue engineering
C. Drug delivery
D. All the above
Answer: D
88. Nanoscience can be studied with the help of ___________ .
A. Quantum mechanics
B. Newtonian mechanics
C. Macro-dynamics
D. Geophysics
Answer: A
89. The compressive strength of a nanotube ________ its tensile strength.
A. is less than
B. is greater than
C. is equal to
D. may be greater than
Answer: A
90. The nanomaterials are used in the light emitted electron luminescent devices.
A. True
B. False
Answer: A
91. Gel electrophoresis separates nucleic acid molecules based on ____________
A. charge on molecules
B. size of the molecules
C. nature of the molecules i.e. whether DNA or RNA
D. chemical properties of the nucleic acids
Answer: B
92. Which of the following is a characteristic of microspheres?
A. Free flowing powders
B. Aqueous solutions
C. Control drug release by partitioning the drug from the oil
D. Administration of emulsions
Answer: A
93. What are the size of Microspheres ?
A. > 200 μm
B. < 200 μm
C. Both a and b
D. None
Answer: B
94. What are the shape of the Microparticulates ?
A. Square
B. Triangle
C. Spherical
D. None
Answer: C
95. Synonyms of the Microspheres………
A. Beads
B. Capsules
C. All
D. None
Ans. : c
96. In microspheres duration of action …………
A. Fast
B. Slow
C. Moderate
D. None
Answer: A
97. Which are the not proper ideal properties of the microspheres ?
A. Longer duration of action
B. Control of content release
C. Protection of drug
D. Decrease of therapeutic efficiency
Answer: D
98. Which are the example of non biodegradable synthetic polymers used in preparation of microspheres?
A. Proteins
B. Poly (acryl) dextran
C. PMMA
D. Lactides
Answer: C
99. Which are the examples of natural material used in preparation of the microspheres?
A. Albumin
B. Gelatin
C. All
D. None
Answer: C
100. The charge present on the DNA backbone is negative. The force required to accelerate the molecules towards anode is directly proportional to the number of ____________
A. sugar molecules
B. nitrogenous bases
C. phosphate groups
D. both phosphate group and sugar molecules
Answer: C
101. Which one of the following will travel fastest through the gel if the amount of DNA present is same in all?
A. Circular
B. Supercoiled
C. Nicked
D. Supercoiled and circular will move at same speed and faster than nicked
Answer: B
102. How is the size of molecules under analysis measured?
A. By measuring the distance moved through a ruler
B. By measuring the amount of visualising dye used
C. By running a standard molecule, whose size is known in parallel
D. There is no exact criterion for doing so
Answer: C
103. Gel matrices are generally of two types Agarose and Polyacrylamide. Which of the statements is correct with respect to agarose gels.
A. Agarose is a polysaccharide which is obtained from red algae
B. Agarose is a polysaccharide obtained from fungus
C. It is composed of glucose residues
D. It is obtained via dissolving in its water by boiling in water and then cooling it
Answer: A
104. Polyacrylamide gels are the other types of gels which are commonly used. Which of the following statement is not correct with respect to these types of gels?
A. They are obtained via polymerization between acrylamide and bis-acrylamide
B. The components added for initiating polymerization are ammonium persulphate and TEMED
C. It is casted in horizontal and flat trays
D. TEMED catalyses the formation of free radicals from persulphate ions which leads to initiation of cross-linking
Answer: C
105. If the amount of agarose added is more, the molecular under analysis should have the following characteristic………………..
A. small size
B. large size
C. size has no relation with the amount of agarose
D. the amount of molecules under analysis matters
Answer: A
106. In the case of electrophoresis of single stranded DNA or RNA, which type of gels are used?
A. Renaturing
B. Denaturing
C. The routine agarose gel
D. The routine polyacrylamide gel
Answer: B
107. The technique used to located specific genes in chromosomes is ……………..
A. Colony Hybridization
B. In situ Hybridization
C. Dot Blot Hybridization
D. Western Blotting
Answer: B
108. The separation of charged molecules under the influence of electric current is called……….
A. Colony Hybridization
B. Dot Blot Hybridization
C. Electrophoresis
D. Western Blotting
Answer: C
109. If further electrophoresis is used for recovery of DNA from gels, the method is termed as____________
A. secondary electrophoresis
B. recovery electrophoresis
C. denaturing electrophoresis
D. electro-elution
Answer: D
110. The greatest separation is obtained in which portion of the gel?
A. Lower portion where the anode is
B. Lower portion where the cathode is
C. The separation is uniform all over
D. It varies according to the quantity of the size of the molecules to be separated
Answer: A