Pharmaceutical Engineering Multiple Choice Questions
1. The working of Fluid energy mill is based on principle of
A. Impact
B. Attrition
C. Cutting
D. Both a & b
Answer:
B. Attrition
2. Size reduction is also known as:
A. Comminution
B. Pulverization
C. Diminution
D. All of the above
Answer:
A. Comminution
3. The bell crank lever arrangement is major part of which of the following………:
A. Cyclone separator
B. Edge runner Mill
C. End runner Mill
D. Bag filter
Answer:
D. Bag filter
4. The hammer mill operates on the principle of:
A. Impact
B. Attrition
C. Compression
D. Cutting
Answer:
A. Impact
5. Ball Mill operates at the speed of?
A. Low speed
B. High speed
C. Optimum speed
D. All of the above
Answer:
C. Optimum speed
6. Fluid Energy Mill works on the principle of:
A. Impact & Attrition
B. Rotor & Stator
C. Compression
D. Attrition
Answer:
A. Impact & Attrition
7. Fibrous drugs are milled by using:
A. Cutter Mill
B. Hammer Mill
C. Fluid Energy Mill
D. Ball Mill
Answer:
A. Cutter Mill
8. Mills are not suitable for Friable (heat sensitive) materials?
A. Cutter Mill
B. Hammer mill
C. Colloidal Mill
D. All of the above
Answer:
D. All of the above
9. In Azeotropic distillation __________ remains low:
A. Heat
B. Volatility
C. Relativity Volatility
D. None of these
Answer:
C. Relativity Volatility
10. In Vacuum Distillation, Substance boils at a/an:
A. Exact temperature
B. temperature slightly above its boiling point
C. temperature below its boiling point
D. High Pressure
Answer:
C. temperature below its boiling point
11. In the fractionating column of fraction distillation, as we go higher in the column the…..?
A. Temperature becomes lower
B. Temperature becomes higher
C. minimum absorption occurs
D. Sublimation risk increases
Answer:
A. Temperature becomes lower
12. Rate of evaporation is______:
A. directly proportional to temperature of liquid
B. inversely proportional to temperature of liquid
C. independent of temperature of liquid
D. directly proportional to humidity of surrounding air
Answer:
A. directly proportional to temperature of liquid
13. Which of the following factors do not affect the rate of evaporation?
A. Temperature of liquid
B. Humidity of surrounding air
C. Depth of liquid
D. Surface of liquid
Answer:
C. Depth of liquid
14. Which of the following is a characteristic of a horizontal tube evaporator?
A. Agitation is provided only by bubbles leaving the evaporator as vapor
B. The tube bundle is arranged vertically, with the solution inside the tubes condensing outside
C. To handle viscous solution a pump is used to force liquid upwards
D. Also called short vertical tube evaporator
Answer:
A. Agitation is provided only by bubbles leaving the evaporator as vapor
15. The (emissivity) of a black body is:
A. 1
B. 1.5
C. 2
D. None
Answer:
A. 1
16. Lyophilization is also known as:
A. Drying by sublimation
B. Freeze drying
C. Both a & b
D. None
Answer:
B. Freeze drying
17. Mean free path is associated with which type of distillation?
A. Steam
B. Evaporative
C. Azeotropic
D. Fractional
Answer:
A. Steam
18. Which one of the following rate is observed in mixing of solids?
A. First order law
B. zero order law
C. Second order law
D. none
Answer:
A. First order law
19. Unit of the rate of heat transfer is
A. Joule
B. Newton
C. Pascal
D. Watt
Answer:
D. Watt
20. Which type of mixture is easily formed?
A. Positive
B. Negative
C. Neutral
D. Ampholytic
Answer:
A. Positive
21. Mechanism not used in solid-solid Mixing:
A. Connective
B. Shear Mixing
C. Diffusion
D. Tumbling
Answer:
D. Tumbling
22. Mechanism of mixing in sigma blade mixer:
A. Connective
B. Tumbling
C. Shearing
D. Diffusion
Answer:
C. Shearing
23. Mechanism of mixing in silverson mixer is:
A. Connective
B. laminar
C. Random
D. Turbulent
Answer:
D. Turbulent
24. Degree of mixing is also known as:
A. Degree of Homogeneity
B. Extent of mixing
C. Ordered Mixing
D. Random Mixing
Answer:
A. Degree of Homogeneity
25. __________ states that the rate of heat flow through a uniform material is proportional to the area and temperature and inversely proportional to the length of the path of flow.
A. Newton’s law
B. Kick’s law
C. Fourier’s law
D. Chatelier’s law
Answer:
C. Fourier’s law
26. A body whose absorptivity is constant at all wavelengths of radiation, at a given temperature is known as
A. Black Body
B. Grey body
C. White Body
D. Shinning body
Answer:
B. Grey body
27. Which of the following is used for drying blood plasma:
A. Spray drying
B. Freeze drying
C. Vacuum Drying
D. Fluid Bed drying
Answer:
B. Freeze drying
28. Which equipment is used for mixing of immiscible liquids?
A. Airjet Mixer
B. Jet Mixer
C. Silverson Mixer
D. Sigma Mixer
Answer:
C. Silverson Mixer
29. Which one of these drying techniques is used for drying antibiotics and plant extract?
A. Vacuum Dryer
B. Freeze dryer
C. Spray dryer
D. None of these
Answer:
B. Freeze dryer
30. ____________ method of distillation is used for the purification & separation of chemicals of low vapor pressure
A. Steam Distillation
B. Destructive distillation
C. Simple Distillation
D. Molecular Distillation
Answer:
D. Molecular Distillation
31. Rectification is another name of:
A. Fractional distillation
B. Molecular distillation
C. Simple distillation
D. Destructive distillation
Answer:
A. Fractional distillation
32. In which dryer, hot air jets are used for drying purpose?
A. Vacuum Dryer
B. Spray Dryer
C. Roller Dryer
D. Fluidized Bed dryer
Answer:
D. Fluidized Bed dryer
33. A black body is perfect
A. Emitter only
B. Absorber only
C. emitter and absorber
D. none of the above
Answer:
C. emitter and absorber
34. What are advantages of the spray drying process:
A. Evaporation is very rapid
B. Most of the heat being used as latent heat of vaporisation
C. The powder will have uniform and controllable particle size
D. All of the above
Answer:
D. All of the above
35. What are physical factors affecting in the selection of the materials for the construction of pharmaceutical plant:
A. Strength
B. Weight
C. Ease of fabrication
D. All of the above
Answer:
D. All of the above
36. Which is not a non-ferrous metal?
A. Copper
B. Aluminum
C. Steel
D. Lead
Answer:
C. Steel
37. Which is used as a placing to protect steel?
A. Asbestos
B. Chromium
C. Glass
D. Rubber
Answer:
B. Chromium
38. For ease in size reduction, the material should be.
A. Hard, brittle
B. Soft, tough
C. Hard, tough
D. Soft, brittle
Answer:
A. Hard, brittle
39. Which of the following factor does NOT affect the size reduction?
A. Hardness
B. Stickiness
C. Viscosity
D. Abrasiveness
Answer:
C. Viscosity
40. Product size achieved by Ball mill?
A. 4-325 mesh
B. 20-200 mesh
C. 20-80 mesh
D. 1-30 microns
Answer:
B. 20-200 mesh
41. Product size achieved by hammer mill is
A. 4-325 mesh
B. 20-200 mesh
C. 20-80 mesh
D. 1-30 microns
Answer:
A. 4-325 mesh
42. Product size achieved by Fluid energy Mill is
A. 4-325 mesh
B. 20-200 mesh
C. 20-80 mesh
D. 1-30 microns
Answer:
D. 1-30 microns
43. Which one is called coarse powder?
A. It is powder in which all the particles must pass through the sieve no. 10
B. It is powder in which all the particles must pass through the sieve no. 22
C. It is powder in which all the particles must pass through the sieve no. 44
D. It is powder in which all the particles must pass through the sieve no. 85
Answer:
A. It is powder in which all the particles must pass through the sieve no. 10
44. Number of sieve is defined as?
A. This is the number of meshes in a length of 25.4 mm in each direction, parallel to the wires
B. This is the number of meshes in a length of 24.5 mm in each direction, parallel to the wires
C. This is the number of meshes in a length of 26.5 mm in each direction, parallel to the wires
D. This is the number of meshes in a length of 28.4 mm in each direction, parallel to the wires
Answer:
A. This is the number of meshes in a length of 25.4 mm in each direction, parallel to the wires
45. Which of these is not a mechanism of size separation?
A. Agitation
B. Brushing method
C. Centrifugal force
D. Compression
Answer:
D. Compression
46. Heat transfer takes place according to
A. First law of thermodynamics
B. Second law of thermodynamics
C. Third law of thermodynamics
D. Zeroth law of thermodynamics
Answer:
B. Second law of thermodynamics
47. Fourier law of heat conduction is based on the assumption that
A. Heat Flow through a solid in one dimension
B. Heat flow is in steady state
C. Both (A) & (B)
D. None of the options
Answer:
C. Both (A) & (B)
48. Which of the following has maximum value of thermal conductivity?
A. Aluminum
B. Steel
C. Brass
D. Copper
Answer:
A. Aluminum
49. Stefan Boltzmann law is applicable for heat transfer by
A. Conduction
B. Convection
C. Radiation
D. Conduction & Radiation combined
Answer:
C. Radiation
50. The amount of radiation mainly depends on:
A. Nature of body
B. Temperature of body
C. Type of Surface of body
D. All of the above
Answer:
D. All of the above
51. The distilled water is collected in _________.
A. Receiver
B. Adapter
C. Condenser
D. Round Bottom Flask
Answer:
A. Receiver
52. Which of the following is not a step in process of distillation?
A. Condensation
B. Heating
C. Precipitation
D. Vaporization
Answer:
C. Precipitation
53. Calendria consists of no. of
A. Baffles
B. Jacket
C. Tubular surfaces
D. None of these
Answer:
C. Tubular surfaces
54. Source of heat in most of the evaporator:
A. Coal
B. Steam
C. Hot water
D. Oil bath
Answer:
B. Steam
55. Solar water heaters, solar cookers, microwave ovens, microwave cookers, sonicator baths etc., are examples of which type transfer of heat mechanism?
A. Conduction
B. Radiation
C. Convection
D. None of these
Answer:
B. Radiation
56. Following factor does NOT influence film coefficient:
A. Thermal conductivity of the liquid
B. Specific heat of the film
C. pH of the liquid
D. Density of the liquid
Answer:
C. pH of the liquid
57. When fluid is heated, the currents set up may cause mixing of fluid. Such heat transfer is known as:
A. Forced Convection
B. Natural Convection
C. Conduction
D. None of these
Answer:
B. Natural Convection
58. Which is NOT a Mode of Size Reduction?
A. Cutting
B. Compression
C. Vaporization
D. Attrition
Answer:
C. Vaporization
59. Following is the example of hammer mill used in Pharmaceutical Industry:
A. Fitzpatrick comminuting machine (Fitz mill)
B. Hardinge Mill
C. Centrifugal impact pulverizer
D. None of these
Answer:
A. Fitzpatrick comminuting machine (Fitz mill)
60. E = KR (Sn – Si) belongs to which law/Theory?
A. Bond’s theory
B. Lacey Theory
C. Kick’s Theory
D. Rittinger’s Theory
Answer:
D. Rittinger’s Theory
61. Bond’s work Index is the work required to reduce a unit weight from a theoretical infinite size to 80% passing ______µm.
A. 10
B. 100
C. 25
D. None of these
Answer:
B. 100
62. A powder, all the particles of which pass through sieve no. 44 is called?
A. Coarse powder
B. Moderately fine powder
C. Fine powder
D. Very fine powder
Answer:
B. Moderately fine powder
63. Herringbone screen recommends use of which type of material for separation?
A. Slurries
B. Fibrous materials
C. Amorphous & crystalline materials
D. Only slurries with coarse particles
Answer:
C. Amorphous & crystalline materials
64. The main principle of Sieve shaker is:
A. Attrition
B. Centrifugation
C. Agitation
D. Compression
Answer:
C. Agitation
65. Sonic sifter is a variant/modification of which of the following equipment?
A. Sieve Shaker
B. Cyclone separator
C. Air separator
D. Bag Filter
Answer:
A. Sieve Shaker
66. Dorrclone is a separator used for separating solid suspended in a liquid such as water, is a modification of which separator?
A. Bag filter
B. Cyclone separator
C. Air separator
D. None of these
Answer:
B. Cyclone separator
67. In mechanism of mixing, which is also known as Macromixing?
A. Shear Mixing
B. Diffusive mixing
C. Both (a) & (b)
D. Convective mixing
Answer:
D. Convective mixing
68. Ideally in mixing equipment, powder should be filled:
A. Not more than 40%
B. Not more than 50%
C. Not more than 60%
D. Not more than 70%
Answer:
C. Not more than 60%
69. In V-Cone Blender, if the speed is increased to high speed, what is observed?
A. Segregation
B. Sedimentation
C. Separation
D. None of these
Answer:
A. Segregation
70. In ribbon blender, the mechanism of mixing follows
A. Trituration
B. Shear
C. Both of these
D. None of these
Answer:
B. Shear
71. Ribbon blender is used to mix:
A. Solid Mixing
B. Liquid mixing-Liquid Mixing
C. Solid-Solid Mixing
D. Both (b) or (c)
Answer:
D. Both (b) or (c)
72. The biggest disadvantage of Sigma Blade mixer is:
A. Size reduction
B. Size separation
C. Fixed speed
D. Dead spots
Answer:
C. Fixed speed
73. In comparison to Ribbon blender, Planetary Mixer has advantage of:
A. High Shear
B. Fixed speed drive
C. Less headspace requirement
D. No Dead space
Answer:
D. No Dead space
74. Aerosol preparations have which phase of mixing?
A. Solid-Liquid Mixing
B. Liquid-Liquid Mixing
C. Liquid-Gas Mixing
D. None of these
Answer:
C. Liquid-Gas Mixing
75. Which of the following is not a part of mixing vessel?
A. Impeller
B. Baffle
C. Calendria
D. Propellers
Answer:
C. Calendria
76. In silverson emulsifier, what is the only disadvantage?
A. Poor Mixing
B. Clogging of pores of the mesh
C. Separation
D. Size reduction
Answer:
B. Clogging of pores of the mesh
77. Hormones, antibiotics & enzymes are:
A. Heat-sensitive
B. Cold-sensitive
C. Volatile
D. None of these
Answer:
A. Heat-sensitive
78. Greater the surface area of the liquid, the evaporation will be:
A. Slow
B. Greater
C. Not affected
D. Both (a) & (b)
Answer:
B. Greater
79. The following Equipment is best for evaporating concentrated aqueous and thermos table liquors:
A. Horizontal Tube evaporator
B. Triple effect evaporator
C. Climbing Film Evaporator
D. Evaporating Pan
Answer:
D. Evaporating Pan
80. Evaporator used to manufacture cascara extract, sugar, salt, caustic soda etc:
A. Vertical Tube evaporator
B. Triple effect evaporator
C. Climbing Film Evaporator
D. None of these
Answer:
A. Vertical Tube evaporator
81. Vertical Tube evaporator is also known as:
A. Horizontal Tube evaporator
B. Basket type evaporator
C. Short Tube Evaporator
D. Rising Film Evaporator
Answer:
C. Short Tube Evaporator
82. Entrainment separator is part of which evaporator?
A. Climbing Film Evaporator
B. Triple effect evaporator
C. Horizontal Tube Evaporator
D. Evaporating Pan
Answer:
A. Climbing Film Evaporator
83. When the feed is high viscosity, following evaporator should be used:
A. Climbing Film Evaporator
B. Falling Film evaporator
C. Horizontal Tube Evaporator
D. Short Tube evaporator
Answer:
B. Falling Film evaporator
84. Evaporator working on basis of Pump or pressure:
A. Climbing Film Evaporator
B. Triple effect evaporator
C. Horizontal Tube Evaporator
D. Forced Circulation Evaporator
Answer:
D. Forced Circulation Evaporator
85. Which evaporator can be modified to Triple effect Evaporator/ Multiple effect evaporator?
A. Vertical Tube Evaporator
B. Forced Circulation evaporator
C. Horizontal Tube Evaporator
D. None of the above
Answer:
A. Vertical Tube Evaporator
86. In distillation process is the separation of the components of a liquid mixture by process involving vaporization and subsequent condensation at another place. What is the feed liquid called?
A. Distillate
B. Condensate
C. Distilland
D. None of the above
Answer:
C. Distilland
87. In which process, concentrated liquid remains as final product?
A. Distillation
B. Evaporation
C. Crystallization
D. Drying
Answer:
B. Evaporation
88. Solution in which there is no change in the properties of the components other than dilution, when they are mixed to form a solution is known as?
A. Ideal Solution
B. Real Solution
C. Fake Solution
D. Partial Solution
Answer:
A. Ideal Solution
89. The correct equation/Expression of Dalton’s Law is:
A. pA = pA XA, pB = po B XB
B. P = pA + pB
C. pA = YA.P, pB = YB.P
D. None of the above
Answer:
B. P = pA + pB
90. Differential Distillation is also known as:
A. Simple Distillation
B. Fractional Distillation
C. Molecular Distillation
D. Steam Distillation
Answer:
A. Simple Distillation
91. Which process is widely used to obtain Water for Injection/Purified Water?
A. Steam Distillation
B. Fractional Distillation
C. Simple Distillation
D. All of the above
Answer:
C. Simple Distillation
92. A process in which the entire liquid mixture is suddenly vaporized by passing the feed from a high pressure zone to a low pressure zone:
A. Simple Distillation
B. Fractional Distillation
C. Steam Distillation
D. Flash Distillation
Answer:
D. Flash Distillation
93. In which process a part of the vapor is condensed and returned as liquid?
A. Fractional Distillation
B. Molecular Distillation
C. Steam Distillation
D. Simple Distillation
Answer:
A. Fractional Distillation
94. Absolute alcohol can be prepared by which method?
A. Molecular Distillation
B. Azeotropic Distillation
C. Fractional Distillation
D. Steam Distillation
Answer:
B. Azeotropic Distillation
95. Which process is based on the principle of Simple Distillation with some modifications?
A. Fractional Distillation
B. Steam Distillation
C. Distillation under reduced Pressure
D. None of these
Answer:
C. Distillation under reduced Pressure
96. Double neck Distillation Flask is known as?
A. Claisen Flask
B. Round Bottom Flask
C. Florentine Flask
D. None of the above
Answer:
A. Claisen Flask
97. High Boiling liquids cannot be purified by simple distillation, since the constituents in the mixture tend to_________________ at higher temperatures.
A. Loose moisture
B. Decompose
C. Become Volatile
D. None of the above
Answer:
B. Decompose
98. Which process is also known as Short-Path Distillation?
A. Simple Distillation
B. Fractional Distillation
C. Steam Distillation
D. Molecular Distillation
Answer:
D. Molecular Distillation
99. Talc has equilibrium Moisture Content (EMC) of practically:
A. One
B. Zero
C. Variable
D. High
Answer:
B. Zero
100. Which of the following type of product is having equilibrium moisture content (EMC) of practically Zero?
A. Non-Porous & Insoluble
B. Non-Porous & Soluble
C. Porous & Insoluble
D. Porous & Soluble
Answer:
A. Non-Porous & Insoluble
101. Dry spots are formed during one of the following period?
A. Constant Rate period
B. First Falling period
C. Initial Adjustment period
D. Second falling period
Answer:
B. First Falling period
102. Eutectic Point is an important factor for one of the following drying processes?
A. Drum Drying
B. Fluidized Bed Drying
C. Tray drying
D. Freeze Drying
Answer:
D. Freeze Drying
103. Filtration is a unit operation that is commonly used for collecting:
A. Filtrate
B. Particulate matter
C. Precipitate
D. Slurry
Answer:
A. Filtrate
104. Who has proposed that the filtration process is similar to the streamline flow of a liquid under pressure through capillaries?
A. Carman
B. Darcy
C. Kozeny
D. Poiseuilli
Answer:
D. Poiseuilli
105. Which is the principle difference in the properties that influences centrifugation?
A. Densities
B. Interfacial Tensions
C. Particle size
D. Viscosities
Answer:
A. Densities
106. Centrifugal method is used for one of the following process:
A. Mixing
B. Purification
C. Separation
D. Sizing
Answer:
C. Separation
107. Water Attack test is performed on glass in order to find the limits of one of the following?
A. Acid liberated
B. Alkali liberated
C. Conductivity
D. Metal ions
Answer:
B. Alkali liberated
108. In Pharmaceutical packing, collapsible tubes made from lead are not used as such, for one of the following reason.
A. Costly metal
B. Difficulty in packing
C. Risk of Poisoning
D. Soft in strength
Answer:
C. Risk of Poisoning
109. One of the following glass containers is used for the storage of light sensitive pharmaceuticals.
A. Air-Tight
B. Amber Colored
C. Unit Dose
D. Well closed
Answer:
B. Amber Colored
110. Containers meant for storage of injections (buffered & unbuffered aqueous solutions) are made from one of the following type of glasses.
A. Borosilicate
B. General Purpose
C. Lime soda
D. Neutral
Answer:
A. Borosilicate
111. Hermetic sealed containers are also known as:
A. Air-Tight Containers
B. Multi-dose containers
C. Single-Dose containers
D. Well-closed containers
Answer:
A. Air-Tight Containers
112. Which metal makes steel corrosion resistant?
A. Copper and selenium
B. Tantalum and molybdenum
C. Chromium and Nickel
D. Titanium and Niobium
Answer:
C. Chromium and Nickel
113. The ability of a metal surface to withstand repeated cycles of corrosion is known as:
A. Cavitation erosion
B. Corrosion fatigue
C. Erosion
D. Stress of corrosion cracking
Answer:
B. Corrosion fatigue
114. Corrosion of metals is fairly high in one of the following medium:
A. Acidic
B. Alkaline
C. Neutral
D. Non-Aqueous
Answer:
A. Acidic
115. Galvanic Corrosion is observed, when external electric current in solution is passed between one of the following combinations:
A. Gold & Platinum
B. Iron & hydrogen
C. Iron & Iron
D. Zinc & Copper
Answer:
D. Zinc & Copper
116. In Cyclone separator, the separation depends on:
A. Size & Shape
B. Shape and Surface area
C. Size & Density
D. Surface texture & Size
Answer:
C. Size & Density
117. One of the theories is NOT applicable to distillation:
A. Graham’s law of diffusion
B. Law of conservation of energy
C. Law of conservation of matter
D. Raoult’s Law
Answer:
A. Graham’s law of diffusion
118. Which product is NOT dried by spray dryer?
A. Serum
B. Fruit Juice
C. Lactose
D. Bacterial & viral cultures
Answer:
D. Bacterial & viral cultures
119. The correct definition of filtration is:
A. When solids are present in a very low concentration, i.e., not exceeding 1.0% w/v, the process of its separation from liquids
B. When solids are present in a very low concentration, i.e., not exceeding 5.0% w/v, the process of its separation from liquids
C. When solids are present in a very low concentration, i.e., not exceeding 2.0% w/v, the process of its separation from liquids
D. When solids are present in a very low concentration, i.e., not exceeding 7.0% w/v, the process of its separation from liquids
Answer:
A. When solids are present in a very low concentration, i.e., not exceeding 1.0% w/v, the process of its separation from liquids