Pharmacology of Cardiovascular Diseases Multiple Choice Questions and Answers Quiz
1. Choose the correct antihypertensive agents and their mechanism of action:
A. Furosemide: inhibition of epithelial sodium transport at the late distal and collecting ducts
B. Losartan: increases aldosterone secretion causing sodium and water retention
C. Clonidine: acts centrally as an a2 agonist causing inhibition of sympathetic vasomotor center
D. a and c
E. a, b and c
Answer: D
4. Which of the following is a direct renin inhibitor?
A. Olmesartan
B. Eplerenone
C. Aliskiren
D. None of the above
Answer: C
5. Choose the cardioselective b-adrenergic blockers.
A. Atenolol
B. Propranolol
C. Betaxolol
D. Carteolol
Answer: A
4. All of the following agents are high ceiling diuretics except:
A. Furosemide
B. Amiloride
C. Torsemide
D. Ethacrynic acid
Answer: D
5. Which of the following statement is true for ACE inhibitors?
A. ACE inhibitors reduce both cardiac preload and afterload, thereby decreasing cardiac work
B. ACE inhibitors increase both angiotensin II and bradykinin levels
C. ACE inhibitors decrease both angiotensin II and bradykinin levels
D. None of the above
Answer: A
6. The cellular action of calcium channel blockers is
A. They inhibit Na + – Ca 2+ exchanger in cardiac and smooth muscles
B. They interact with the L-type voltage-gated channel
C. Their interaction with the sodium pump results in the inhibition of calcium transport
D. Their interaction with the membrane phospholipids results in a nonselective decrease in ion transport
Answer: B
7. Following are the pharmacological management of myocardial infarction to prevent future heart attacks
A. Platelet inhibitors
B. b-blockers
C. Control of hyperlipidemia
D. All of the above
E. None of the above
Answer: D
8. The cellular mechanism action of digoxin is:
A. Inhibition of cAMP synthesis
B. Inhibition of b-adrenergic stimulation
C. Inhibition of ATP degradation
D. Inhibition of Na + K + ATPase
Answer: D
9. Which of the following drugs provide significant relaxation of smooth muscles of both venules and arterioles?
A. Nifedipine
B. Diazoxide
C. Sodium nitroprusside
D. Minoxidil
Answer: C
10. Which of the following drugs is not used for the management of congestive heart failure?
A. Enalapril
B. Nifedipine
C. Propranolol
D. Digoxin
Answer: B
11. Which of the following class of anti-arrhythmic drug suppresses abnormal automaticity and permit the sinoatrial node to again assume the role of a dominant pacemaker?
A. Class I
B. Class II
C. Class III
D. Class IV
Answer: A
12. The anticoagulant effect of heparin is explained by…………………………………………
A. Chelation of calcium ion
B. Reduction of vitamin k dependent factor
C. Activation of antithrombin III
D. Activation of plasmin
Answer: C
13. If quinidine and digoxin are administered concurrently, what effect does quinidine have on digoxin?
A. Plasma concentration of digoxin is increased
B. Absorption of digoxin from the gastrointestinal tract is decreased
C. Effect of digoxin on the AV node is antagonized
D. Metabolism of digoxin is prevented
Answer: A
14. The specific antidote for Heparin is;
A. Pralidoxime
B. Protamine sulfate
C. Vitamin K
D. EDTA
Answer: B
15. The therapeutic benefit of propranolol in angina is believed to be primarily due to:
A. Reduced production of catecholamines
B. A decreased requirement of myocardial oxygen
C. Increased sensitivity to catecholamines
D. Increased peripheral resistance
Answer: B
16. Low concentration of nitrates cause dilation of:
A. Large arteries
B. Veins
C. Precapillary sphincters
D. Arterioles
Answer: B
17. Following is the mechanism of action of HMG-CoA reductase inhibitors
A. Competitive inhibition of HMG-CoA reductase
B. Reduction in endogenous cholesterol synthesis
C. Up-regulation of LDL receptor activity
D. None of above
E. All of the above
Answer: E
18. Nicotinic acid is;
A. Lipid modifying agent
B. Thrombolytic
C. Anticoagulant
D. Antiplatelet agent
Answer: A
19. A 46-year old man has been successfully treated with a thiazide diuretic for the last 5 years. Over the last 4 months, his diastolic pressure has steadily increased, and he has been kept on additional antihypertensive medication. He complains of several instances of being unable to achieve an erection and that he is no longer able to complete 3 sets of tennis. Which of the following second antihypertensive drug is most likely to cause the above mentioned complains?
A. Metoprolol
B. Captopril
C. Losartan
D. Nifedipine
Answer: A
20. Which of the following drug is a K+ channel opener?
A. Amiodarone
B. Nicorandil
C. Nifedipine
D. Captopril
Answer: B