Microbiology Problems focuses on “Viruses Containing Double – Stranded DNA”.
1. What is the shape of the nucleoid of poxviruses?
A. circular
B. brick-shaped
C. irregular
D. dumbbell-shaped
Answer: D
Clarification: Poxviruses contain double-stranded DNA, protein, and lipid and have a dumbbell-shaped nucleoid surrounded by two membrane layers.
2. The fatality rate for variola minor is ____________
A. 10-30%
B. 1-5%
C. 0.1-0.3%
D. 60-80%
Answer: C
Clarification: The less virulent variola minor (alastrim) has a fatality rate of only 0.1 to 0.3 percent which is very less in comparison to that of variola major.
3. For diagnosis of Smallpox viruses demonstration of Negri bodies is carried out.
A. True
B. False
Answer: B
Clarification: For diagnosis of Smallpox viruses the use of light microscopy to demonstrate inclusion bodies i.e., Guarnieri bodies in stained cells is carried out.
4. Which strain of adenoviruses can cause cancer?
A. Subgroup I
B. Subgroup II
C. Subgroup III
D. Subgroup IV
Answer: D
Clarification: Adenoviruses particularly those of subgroup IV can cause cancer or are oncogenic when inoculated into immunodeficient animals (newborn hamsters).
5. MDV virus affects which of the following?
A. chickens
B. cattle
C. humans
D. birds
Answer: A
Clarification: One of the animal herpesviruses is Marek’s disease virus (MDV), which affects the epithelium of feather follicles in chickens.
6. HSV-1 has been recognized as the causative agent of disease involving the genital tract.
A. True
B. False
Answer: B
Clarification: HSV-2 has been recognized as the causative agent of primary and recurrent disease involving the genital tract.
7. Which drug is used for healing genital herpes?
A. acyclovir
B. penicillin
C. erythromycin
D. tetracycline
Answer: A
Clarification: Topical application of the drug acyclovir can shorten the healing time in primary genital herpes but has little effect in the treatment of the recurrent form.
8. Mononucleosis is caused by which of the following viruses?
A. VZV
B. HSV
C. EBV
D. HIV
Answer: C
Clarification: Epstein-Barr Virus (EBV) is the causative agent of infectious mononucleosis, a self-limiting disease that occurs in up to 80 percent of the population.
9. What is the size of papillomaviruses?
A. 30 nm
B. 45 nm
C. 2 nm
D. 55 nm
Answer: D
Clarification: The Papovaviruses are divided into two major groups among which one is papillomaviruses which are 55 nm in diameter.
10. SV 40 causes diseases in which animals?
A. monkeys
B. rabbits
C. humans
D. cattle
Answer: A
Clarification: SV 40 occurs in monkeys and it was first discovered as a latent virus in cultures of rhesus monkey kidney cells.
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