Pharmaceutical Chemistry Multiple Choice Questions
1. D and L are a pair of……………. configuration
A. Relative
B. Absolute
C. Cis-trans
D. Optical
Answer: A
2. The term atropiisomerism is used for isomers
A. That can be interconverted by rotation about single bonds
B. That are geometrical isomers
C. That are enantiomers
D. That are optical isomers
Answer: A
3. The separation of racemic mixture into the pure enantiomer is
A. Racemization
B. Resolution
C. Isomerization
D. All of the above
Answer: B
4. A meso compound
A. Is an achiral molecule that contains chirality central
B. Contains plane of symmetry
C. Is optically inactive
D. Is characterized by all of the above
Answer: D
5. R and S are a pair of …………….. configuration.
A. Relative
B. Absolute
C. E-Z
D. Optical
Answer: B
6. d and l are a pair of………….. configuration
A. Relative
B. Absolute
C. E-Z
D. Optical isomers
Answer: D
7. A bond in which atoms share a pair of electrons is
A. Ionic bond
B. Covalent bond
C. Electrovalent bond
D. Binary compound band
Answer: B
8. ………..is a heterocyclic compound with three membered ring.
A. Furans
B. Pyrroles
C. Ethylene oxide
D. Cyclo propane
Answer: C
9. ………………is a heterocyclic compound with five membered ring.
A. Aziridine
B. Azoletine
C. Azole
D. Azoline
Answer: C
10. 1,2-postion with six members heterocyclic contain two nitrogen atom is called
A. Pyrimidine
B. Pyridine
C. Pyrazine
D. Pyridazine
Answer: D
11. 1,3-postion with six member heterocyclic contain two nitrogen atom is called
A. Pyrimidine
B. Pyridine
C. Pyrazine
D. Pyridazine
Answer: A
12. A gas whose molecule is monatomic is
A. Oxygen
B. Helium
C. Nitrogen
D. Chlorine
Answer: B
13. A reaction between an acid and an alcohol produces an ester and
A. Carbon dioxide
B. Water
C. Glycerol
D. Ethanol
Answer: B
14. Removal of hydrogen from alkene product an
A. Alcohol
B. Alkane
C. Alkyne
D. Protein
Answer: C
15. Which of the following intermediates has a positive charge?
A. Carbocation
B. Carbanion
C. Carbene
D. Nitrene
Answer: A
16. Which of the following intermediates has a negative charge?
A. Carbocation
B. Carbanion
C. Carbene
D. Nitrene
Answer: B
17. Which of the following is a nitrogen analog of carbene?
A. Carbocation
B. Carbanion
C. Carbene
D. Nitrene
Answer: D
18. Which of the following groups comes under EDG?
A. Nitro
B. Chloro
C. Amino
D. Aldehyde
Answer: C
19. Which of the following groups comes under EWG?
A. Nitro
B. Methyl
C. Amino
D. Anilide
Answer: A
20. Which of the following rules is not used to determine the electronic configuration?
A. Paul’s
B. Saytzeff
C. Hund’s
D. Aufbau
Answer: B
21. All statements are correct for SN-1 Reaction, except
A. Follows first-order kinetic
B. Rearrangement is possible
C. Inversion of configuration takes place
D. Two-step reaction
Answer: C
22. All statements are correct for SN-2 Reaction, except
A. Follows second-order kinetic
B. Rearrangement is possible
C. Inversion of configuration takes place
D. Single step reaction
Answer: B
23. All statements are correct for E-2 reaction, except
A. Follows first order kinetic
B. Reactivity order is 3°>2°>1°
C. Always β-hydrogen abstracted
D. Single-step reaction
Answer: A
24. Saturated farry acid with four carbon atoms is known as.
A. Acetic acid
B. Buytric acid
C. Valeric acid
D. Propionic acid
Answer: B
25. Orientation of elimination reaction follows…
A. Markoniov’s rule
B. Saytzeff rule
C. Michael addition
D. Bredt’s Rule
Answer: B
26. Orientation of addition reaction follows..
A. Markoniov’s rule
B. Saytzeff rule
C. Michael addition
D. Bredt’s Rule
Answer: A
27. Which of the following is a polar aprotic solvent?
A. DMF
B. Etahanol
C. Water
D. Chloroform
Answer: A
28. Which of the following is a polar protic solvent?
A. Acetic acid
B. Etahanol
C. Water
D. All
Answer: D
29. In which of the following structures, geometrical isomer is not possible?
A. Ethene
B. Propene
C. 2-Pentene
D. A and B
Answer: D
30. How many isomers are present in the structure of glucose?
A. 12
B. 16
C. 10
D. 4
Answer: B
31. Which from is more stable in confirmation of n-butane ?
A. Skew staggered
B. Skew eclipsed
C. Totally staggered (anti)
D. Fully eclipsed
Answer: C
32. All statements are correct for enantiomer, except
A. It must be a chiral
B. Not superimposable on its mirror image
C. Gives optical activity
D. All enantiomer are optically active
Answer: D
33. Compound A is highly volatile and insoluble in water so bonding in A is
A. Coordinate bond
B. Ionic bond
C. Covalent bond
D. Polar covalent bond
Answer: C
34. Which form is more stable in confirmation of cyclohexane?
A. Chair
B. Boat
C. Twist boat
D. Half chair
Answer: A
35. Which of the following is an example of cyclic ether?
A. Oxiran
B. Epoxide
C. Cyclobutane
D. A and B
Answer: D
36. The nomenclature of geometrical isomer is done by
A. R and S
B. d and l
C. E and Z
D. D and L
Answer: C
37. Which of the following is type of structure isomers?
A. Tautomerism
B. Metamerism
C. Functional isomerism
D. All of the above
Answer: D
38. Higher ring strain is associated with
A. Cyclopropane
B. Cyclobutane
C. Cyclopentane
D. Cyclohexane
Answer: A
39. Staggered and eclipsed is a type of
A. Conformational isomer
B. Geometrical isomer
C. Enantiomer
D. Optical isomer
Answer: A
40. Which of the following statement is not correct for benzene?
A. Heat of hydrogenation and combustion are lower than expected value
B. Benzene undergoes addition reaction rather than substitution reaction
C. All C=C in benzene have an intermediate bond length between C-C and C=C
D. Benzene follows huckel’s rule
Answer: B
41. Which of the following is ortho-para directing group?
A. Nitro
B. Ester
C. Methyl
D. 4° ammonium compound
Answer: C
42. Which of the following is a meta directing group?
A. Chloro
B. Cyno
C. Anilide
D. Alkoxy
Answer: B
43. Which of the following is not aromatic?
A. Cyclopentadiene anion
B. Cyclopentadiene
C. Anthracene
D. Napthalene
Answer: B
44. The migration of a group from carbon to electron deficient oxygen is an example of ………. reaction.
A. Baeyer – Villiger rearrangements
B. Pinacole-Pinacolone rearrangements
C. Beckmann rearrangements
D. Benzillic acid rearrangements
Answer: A
45. Which reaction involves migration of group from carbon to nitrogen?
A. Baeyer – Villiger rearrangements
B. Pinacole-Pinacolone rearrangements
C. Beckmann rearrangements
D. Benzillic acid rearrangements
Answer: C
46. The number of optically active isomers of tartanic acid is
A. 2
B. 3
C. 4
D. 5
Answer: A
47. By the presence of a halogen atom in the ring, what is the effect of this on basic properties of aniline?
A. Increased
B. Decreased
C. Unchanged
D. Doubled
Answer: B
48. Mixture of amino acid can be separated by
A. Sublimation
B. Chromatography
C. Distillation
D. None
Answer: B
49. Spraying reagent used in detection of amino acid is
A. Iodine solution
B. Benedict reagent
C. Molisch reagent
D. Esterification
Answer: D
50. Sodium in liquid ammonia is used in………. type of reaction.
A. Birch reduction
B. Wolff kishner Reduction
C. Clemmensen reduction
D. Stephen reduction
Answer: A