[Chemistry Class Notes] on Stereochemistry Pdf for Exam

Stereochemistry, an important subcategory of chemistry, involves the study of the relative spatial arrangement of atoms that form the structure of molecules and their manipulation. For this reason, it is also known as 3D chemistry in which the prefix “stereo” means “three-dimensionality”.

Using this formulation of stereochemistry procedures, any chemist can work out the relationships between different molecules that are made up of the same category of atoms. They can even study the effect on the physical or biological properties these relationships give molecules. An important part of stereochemistry is the study of chiral molecules and this serves as a really useful part of the chemistry to the students which might help them in the future.

Chemistry is really important and efficient for the research and study of living organisms because it helps students and scientists to understand the life processes of every living thing on earth at the molecular level. At any molecular level, every process of life takes place due to the involvement of various minor or major chemical reactions.

Thus, it is important for the students to learn their chapters well and understand all the chemistry concepts by practicing with a maximum number of past years’ question papers and sample question papers available on the website. This will help them to understand the time management skill and learn the marking schemes that carry maximum marks and plan which question needs what type of answers. Break down larger portions into smaller effective points and write them down in a separate notebook so it will help you in revising before the exams. Make note of the important questions that keep repeating in the recent past year question papers and give more weightage to those questions and prepare a little extra because it might repeat in the current year also. If you have any doubts about the equations and chemical formulations that are taught during the classes then try to spend some extra time in the lab and get to understand all the concepts by trying out the experiments and practicing them really well. This will definitely help you write your formulas and equations really well.

Brief About Stereochemistry

Stereochemistry is defined as the branch of chemistry which involves “the study of various spatial arrangements of atoms present in molecules”.

Stereochemistry is described as the systematic presentation of a particular field of science and technology traditionally requiring a short preliminary excursion into history. Stereochemistry is also called the ‘chemistry of space ‘, which is stereochemistry that deals with the spatial arrangements of groups and atoms in a molecule.

More about Stereochemistry

Stereochemistry is capable of tracing its roots to 1842 when the French chemist, named, Louis Pasteur made an observation, which the salts of tartaric acid collected from a vessel of wine production which has the ability to rotate plane-polarized light, whereas similar salts from various sources did not hold this ability. This whole phenomenon is explained by optical isomerism.

Types of Stereoisomers

Different types of stereoisomers are tabulated below. Let us discuss more about them.

 

Stereoisomerism

Stereoisomerism is known as “the isomerism, which is caused by the non-similar arrangements of functional groups or atoms that belong to an atom in space”. These kinds of isomers contain similar constitutions, but various geometric arrangements of atoms. Stereoisomers are broadly classified into two types, which are enantiomers and diastereomers.

Enantiomers

When two isomers are explained as the mirror images of each other, such type of isomerism is known as enantiomerism, and these types of isomers are called enantiomers.

 

Enantiomers are the isolable and stable compounds that vary in their spatial arrangements in 3-D space.

 

Generally, they exist as discrete pairs.

 

The properties of enantiomers are identical. However, their interaction with any plane of the polarized light can differ.

 

The direction, towards which they rotate the plane-polarized light is much different, it means, if one rotates in the right direction, the other rotates towards the left direction.

Diastereomers

When any two isomers are not behaving as mirror images of each other, they are referred to as diastereomers.

 

A molecule with an ‘n’ number of asymmetric carbon atoms can have up to ‘2n’ diastereomers.

 

When two diastereomers vary at only one stereocenter, they are called epimers.

 

These isomers change in both physical properties and chemical reactivity.

 

A representation of enantiomers which are mirror images of each other is given below.

Importance of Stereochemistry – Thalidomide Disaster

The atoms arrangement in three-dimensional space plays a major part in the molecule properties.

 

An example of the stereochemistry significance is observed in the thalidomide disaster which struck Germany in 1957.

 

This drug thalidomide was sold in the form of an over-the-counter drug, where it was initially intended to combat nausea. It can also be used by pregnant women to alleviate morning sickness.

 

However, it was discovered that this drug underwent racemization and was produced as an enantiomers mixture in the human body because of the metabolism process.

 

One of these enantiomers can be believed to cause some genetic damage in the development of embryos and lead to baby birth defects.

 

This is based on the data that over 5000 babies were born with the deformed limbs shortly after thalidomide sold commercially as an over-the-counter drug.

 

This unforeseen effect of the drug has led to the imposition of stricter drug regulation laws (only 40 per cent of the born babies with these deformities survived).

 

This disaster signifies stereochemistry’s importance.

Facts about Stereochemistry

The structure of the molecule can change according to the three-dimensional arrangement of the atoms that constitute this. Also, Stereochemistry deals with the atom’s arrangement manipulation.

 

Commonly, this branch of chemistry can be referred to as 3-D chemistry because it focuses on the stereoisomers (which are the chemical compounds with similar chemical formulas but with a different spatial arrangement in these three dimensions).

 

A branch of stereochemistry deals with the molecule’s study that exhibits chirality, which is a property of the geometry of molecules that makes them non-superimposable on their mirror images.

 

Another branch of the three-dimensional chemistry, which is called dynamic stereochemistry, involves the study of the effects of various spatial arrangements of the atoms, present in a molecule on the rate of a chemical reaction.

Stereochemistry and Regiochemistry

The arrangement of stereoisomers can be described by stereochemistry. The key distinction between stereochemistry and regiochemistry is, the final result’s atomic structure of a chemical reaction can be represented using regiochemistry, whereas stereochemistry describes the atomic arrangement and the modification of these molecules.