Both regulators and conformers get affected by climatic changes. Temperature variations affect their longevity and aging. It is found that animals living in cool climates live longer. And an increase in temperature over time affects the lifespans of animals. This is because, at low temperatures, enzymes become inhibited, but in high temperatures, respiratory and circulatory systems struggle to meet oxygen demand. This negatively affects protein structure and function, membrane fluidity, and gene expression. Thus, resulting in accelerated biochemical pathways resulting in a higher rate of metabolism. All of these make the animals more prone to diseases.
On the other hand, in colder climates, the neuroendocrine processes resulting from low temperatures are correlated to slower aging and a longer life span. Therefore, animals, be they regulators or conformers, face challenges with regard to climate change.