Life Sciences MCQs focuses on “Cells of Immune System”.
1. Which of the following cell is a multipotent cell?
A. T-cell
B. B-cell
C. HSC
D. Monocytes
Answer: C
Clarification: Hematopoitic stem cell (HSC. can give rise to a number of cells by following two pathways and known as a multipotent cell. One pathway gives lymphoid progenitor cell while others give myeloid progenitor cell.
2. Mark the one, which is NOT a lymphoid progenitor cell.
A. Monocyte
B. B-cell
C. T-cell
D. NK cells
Answer: A
Clarification: Monocyte is a myeloid progenitor cell and is a part of white blood cells. B-cells, T-cells, and NK cells are lymphoid progenitor cells.
3. What is the origin of B-cell?
A. Pancreas
B. Liver
C. Thymus
D. Bone marrow
Answer: D
Clarification: The origin and maturation of B-cell take place in the bone marrow itself while in birds B-cells originate from bone marrow but mature in the bursa of fabricius.
4. NK cells can kill their target even in the absence of antigen.
A. True
B. False
Answer: A
Clarification: NK cells are natural killer cells, which use perforin and granzyme to kill the target cell. They can destroy malignant and virus infected cells even without the prior exposure to antigen, hence they can kill their target even without specific antigen.
5. Chediak-Higashi syndrome is caused due to deficiency of_________
A. Nutrophils
B. Nk cells
C. Basophils
D. Mast cell
Answer: B
Clarification: Chediak-Higashi syndrome is an autosomal recessive disorder which is caused by the deficiency of NK cells.
6. Which of the following is NOT polymorphonuclear leukocytes?
A. Eosinophils
B. Mast cell
C. Macrophages
D. Basophils
Answer: C
Clarification: Polymorphonuclear leukocytes are those that have irregular-shaped nuclei with more than two lobes. Their cytoplasmic matrix is rich in substances which can kill microorganisms and increase inflammation.
7. Which of the following cells has a high affinity receptor for IgE?
A. Dendritic cell
B. Mast cells
C. Eosinophils
D. Basophils
Answer: D
Clarification: Basophils are non-phagocytic cells, which releases substance that causes an allergic responses. These substances are histamine, prostaglandins, serotonins etc. It has a high affinity for IgE.
8. Name the macrophages which are associated central nervous system.
A. Alveolar macrophages
B. Kupffer cell
C. Mesangial
D. Microglial cells
Answer: D
Clarification: Macrophages are phagocytic in nature and is derived from blood monocytes. They have a variety of forms like kupffer cells in the liver, mesangial in the kidney, and alveolar macrophages in the lung.
9. Name the molecule which constitutively expressed on the dendritic cell?
A. Class I MHC
B. Class II MHC
C. APC
D. Antigen
Answer: B
Clarification: Dendritic cells arise from both myeloid and lymphoid lineages. Inspite of their differences, they all express high level of class II MHC and act as an antigen presenting cells.
10. Name the dendritic cell, which does not function as antigen presenting cell?
A. Follicular dendritic cell
B. Langerhans cell
C. Myeloid dendritic cell
D. Lymphoid dendritic cell
Answer: A
Clarification: Follicular dendritic cell has a different function than antigen presenting cell as they do not arise from the bone marrow and also do not express MHC II molecules on their surface.
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